OBJECTIVE— Tall-like receptor (TLR)4 has been implicated in the pathogenesis of free
fatty acid (FFA)-induced insulin resistance by activating inflammatory pathways, including …

Accumulating evidence from animal studies suggest that chronic elevation of circulating
intestinal-generated lipopolysaccharide (LPS) (ie, metabolic endotoxemia) could play a role in …

NF-κB is a transcription factor that controls the gene expression of several proinflammatory
proteins. Cell culture and animal studies have implicated increased NF-κB activity in the …

Type 2 diabetes is characterized by fasting hyperglycemia, secondary to hepatic insulin
resistance and increased glucose production. Peroxisome proliferator-activated receptor-γ …

Key points • Reducing free fatty acids in the circulation gives protection against muscle insulin
resistance. • In the present study, we investigated the mechanism by which free fatty acid …

OBJECTIVE—To quantitate insulin sensitivity in lean and obese nondiabetic baboons and
examine the underlying cellular/molecular mechanisms responsible for impaired insulin …

Insulin stimulates glycogen synthase (GS) through dephosphorylation of serine residues, and
this effect is impaired in skeletal muscle from insulin-resistant [obese and type 2 diabetic (…

Several lines of evidence have pointed out that genetic components have roles in thyrotoxic
hypokalemic periodic paralysis (TTPP). In this study, for the first time we performed genome-…

Background. Exercise has an anti-inflammatory effect against, and immune cells play critical
roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD). …

Local epidemiological data on the etiologies of in-patients who are hospitalized with CAP is
needed to develop guidelines for clinical practice. This study was conducted to determine …