Spontaneous mouse models of cancer show promise to more accurately recapitulate human
disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to …

The concept of cancer stem cells suggests that there are malignant stem-like cells within a
tumor that are responsible for tumor renewal and resistance to cytotoxic therapies. Studies …

Antibiotic-treated mice orally inoculated with one of threeCandida albicans strains (including
two mutant strains) or indigenous Candida pelliculosa showed levels of candidal …

: Clostridium difficile toxins A and B are the widely recognized etiologic agents of
antibioticassociated diseases ranging from diarrhea to pseudomembranous colitis. We hypothesized …

Infections with Candida albicans have become a significant problem among very low birth
weight infants in the neonatal intensive care unit. Risk factors are multiple and include …

In this study, we evaluated the efficacy of virtual microscopy as the primary mode of laboratory
instruction in undergraduate level clinical hematology teaching. Distance education (DE) …

To create a model in which to study the effects of RAS dysregulation in hematopoietic
disease, we developed separate founder lines of transgenic mice, with the tetracycline …

Glioblastoma multiforme (GBM), the most common primary central nervous system neoplasm,
is a complex, heterogeneous disease. The recent identification of stem cells in murine …

Objective Systemic candidiasis is a major cause of complicating infections in intensive care
units. Morbidity and mortality are high, even in those who receive appropriate antifungal …

Juvenile myelomonocytic leukemia is a rare myeloproliferative neoplasm characterized by
hyperactive RAS signaling. Neurofibromin1 (encoded by the NF1 gene) is a negative …