Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures
…, S Edwards, MM Kimberly, WJ Korzun… - Clinical …, 2010 - academic.oup.com
Background: Methods from 7 manufacturers and 1 distributor for directly measuring HDL
cholesterol (C) and LDL-C were evaluated for imprecision, trueness, total error, and specificity …
cholesterol (C) and LDL-C were evaluated for imprecision, trueness, total error, and specificity …
Non–HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic …
…, S Edwards, MM Kimberly, WJ Korzun… - Clinical …, 2011 - academic.oup.com
BACKGROUND Our objective was to evaluate the accuracy of cardiovascular disease (CVD)
risk score classification by direct LDL cholesterol (dLDL-C), calculated LDL cholesterol (…
risk score classification by direct LDL cholesterol (dLDL-C), calculated LDL cholesterol (…
Leutusome: a biomimetic nanoplatform integrating plasma membrane components of leukocytes and tumor cells for remarkably enhanced solid tumor homing
Cell membrane-camouflaged nanoparticles have appeared as a promising platform to develop
active tumor targeting nanomedicines. To evade the immune surveillance, we designed …
active tumor targeting nanomedicines. To evade the immune surveillance, we designed …
[HTML][HTML] Procalcitonin identifies cell injury, not bacterial infection, in acute liver failure
JA Rule, LS Hynan, N Attar, C Sanders, WJ Korzun… - PloS one, 2015 - journals.plos.org
Background Because acute liver failure (ALF) patients share many clinical features with
severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is …
severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is …
Nanoparticle-based “Two-pronged” approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux
H He, J Wang, PJ Yannie, WJ Korzun, H Yang… - Biomaterials, 2020 - Elsevier
Reduction of lipoprotein uptake by macrophages and stimulation of cholesterol efflux are
two essential steps required for atherosclerotic plaque regression. We used the optimized …
two essential steps required for atherosclerotic plaque regression. We used the optimized …
Over-expression of intestinal alkaline phosphatase attenuates atherosclerosis
…, YK Sandhu, G Kakiyama, WJ Korzun… - Circulation …, 2021 - Am Heart Assoc
Rationale: Intestinal alkaline phosphatase (IAP) is secreted by enterocytes and is present on
the apical surface. It not only detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the …
the apical surface. It not only detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the …
Evaluation of four different equations for calculating LDL-C with eight different direct HDL-C assays
…, MM Kimberly, RD Shamburek, WJ Korzun… - Clinica Chimica …, 2013 - Elsevier
BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) is often calculated (cLDL-C) by
the Friedewald equation, which requires high-density lipoprotein cholesterol (HDL-C) and …
the Friedewald equation, which requires high-density lipoprotein cholesterol (HDL-C) and …
[HTML][HTML] Dietary Supplementation with Galactooligosaccharides Attenuates High-Fat, High-Cholesterol Diet-Induced Glucose Intolerance and Disruption of Colonic …
…, J Wang, PJ Yannie, YK Sandhu, WJ Korzun… - The Journal of …, 2020 - Elsevier
Background A Western-type diet (WD), rich in fat and cholesterol but deficient in fiber,
induces development of diabetes and atherosclerosis. Colonic bacteria use the gut's mucous …
induces development of diabetes and atherosclerosis. Colonic bacteria use the gut's mucous …
Oral creatine supplements lower plasma homocysteine concentrations in humans
WJ Korzun - American Society for Clinical Laboratory Science, 2004 - clsjournal.ascls.org
OBJECTIVE: To determine if oral creatine supplements will lower the concentration of total
plasma homocysteine (tHcy). SETTING/PARTICIPANTS: Apparently healthy volunteers, at …
plasma homocysteine (tHcy). SETTING/PARTICIPANTS: Apparently healthy volunteers, at …
[HTML][HTML] The signal transducer and activator of transcription 1 (STAT1) inhibits mitochondrial biogenesis in liver and fatty acid oxidation in adipocytes
…, J Meier, M Cantwell, K Szczepanek, WJ Korzun… - PLoS …, 2015 - journals.plos.org
The transcription factor STAT1 plays a central role in orchestrating responses to various
pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, …
pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, …
