Suppression of antimicrobial resistance in MRSA using CRISPR-dCas9

K Wang, M Nicholaou - American Society for Clinical Laboratory …, 2017 - clsjournal.ascls.org
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) are genetic
elements that function with CRISPR-Associated (Cas) proteins as an adaptive immune …

Functional Characterization of Type III-A CRISPR-Cas in a Clinical Human Methicillin-R Staphylococcus aureus Strain

Y Li, K Mikkelsen, O Lluch i Grane, Z Wang… - The CRISPR …, 2021 - liebertpub.com
CRISPR with its cas genes is an adaptive immune system that protects prokaryotes against
foreign genetic elements. The type III-A CRISPR-Cas system is rarely found in …

[HTML][HTML] Study the features of 57 confirmed CRISPR loci in 38 strains of Staphylococcus aureus

X Zhao, Z Yu, Z Xu - Frontiers in microbiology, 2018 - frontiersin.org
Staphylococcus aureus is a foodborne pathogen that causes food contamination and food
poisoning, which poses great harm to health, agriculture and other hosts. Clustered …

Identification and Characterization of the CRISPR/Cas System in Staphylococcus aureus Strains From Diverse Sources

EA Cruz-López, G Rivera… - Frontiers in …, 2021 - frontiersin.org
The CRISPR-Cas [clustered regularly interspaced short palindromic repeats and the
CRISPR-associated genes (Cas)] system provides defense mechanisms in bacteria and …

The application of the CRISPR-Cas system in antibiotic resistance

S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus

L Cao, CH Gao, J Zhu, L Zhao, Q Wu, M Li… - International Journal of …, 2016 - Elsevier
The CRISPR-Cas (clustered regularly interspaced short palindromic repeats [CRISPR]-
CRISPR associated proteins [Cas]) system can provide prokaryote with immunity against …

Tailor-made gene silencing of Staphylococcus aureus clinical isolates by CRISPR interference

Y Sato'o, J Hisatsune, L Yu, T Sakuma, T Yamamoto… - PLoS …, 2018 - journals.plos.org
Preparing the genetically modified organisms have required much time and labor, making it
the rate-limiting step but CRISPR/Cas9 technology appearance has changed this difficulty …

CRISPR in modulating antibiotic resistance of ESKAPE pathogens

U Saha, R Gondi, A Patil, SD Saroj - Molecular Biotechnology, 2023 - Springer
Abstract The ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae,
Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) isolates both …

Expression and purification of the Cas10-Csm complex from staphylococci

L Chou-Zheng, A Hatoum-Aslan - Bio-protocol, 2017 - bio-protocol.org
CRISPR-Cas (Clustered regularly interspaced short palindromic repeats-CRISPR-
associated proteins) is a class of prokaryotic immune systems that degrade foreign nucleic …

CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens

MAB Shabbir, MZ Shabbir, Q Wu, S Mahmood… - Annals of Clinical …, 2019 - Springer
The development of antibiotic resistance in bacteria is a major public health threat. Infection
rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led …