DATA SOURCES: Current literature DATA SYNTHESIS: Acute lymphoblastic leukemia (ALL)
is a stem cell disorder characterized by an overproduction of lymphoblasts in the bone …

There has been exponential growth in our understanding of the pathobiology of acute
lymphoblastic leukemia (ALL) leading to the discovery of new prognostic markers and …

Progress in treatment and in the understanding of disease biology has been continuous in
acute lymphoblastic leukemia (ALL) over the last 50 years. At present, the survival rate in …

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted
therapy and detailed understanding of the genetic alterations driving leukemogenesis and …

Acute leukemia (AL) is a family of blood cancers that arises from the malignant
transformation of hematopoietic cells of lymphoid (acute lymphoblastic leukemia (ALL)) or …

Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a
heterogeneous disease in which many genetic lesions result in the development of multiple …

The notable success of therapy for acute lymphoblastic leukemia (ALL) in children, for whom
cure rates now exceed 80% to 90%, is even more remarkable when one considers that …

The outcomes of pediatric acute lymphoblastic leukemia (ALL) have improved remarkably
during the last five decades. Such improvements were made possible by the incorporation of …

Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood but is rare
in adults. Great strides have been made in the treatment and cure of children with ALL, with …

Acute lymphoblastic leukemia is a heterogeneous disease comprising several clinico-
biological entities. Karyotyping of leukemic cells identifies recurrent chromosome …