A Modified Sodium Metabisulfite Method to Distinguish Sickle Cell Disease from Sickle Cell Trait for Use in Underdeveloped Countries

TR Randolph, A Le, J DeMond - American Society for Clinical …, 2019 - clsjournal.ascls.org
The objective of this study was to develop a simple, inexpensive, and rapid confirmatory test
using a sodium metabisulfite microscopic method to distinguish AS from SS genotype in …

Novel test method (sickle confirm) to differentiate sickle cell anemia from sickle cell trait for potential use in developing countries

TR Randolph, J Wheelhouse - American Society for Clinical …, 2012 - clsjournal.ascls.org
The objective of this study was to develop a diagnostic testing method to detect HbS,
distinguish sickle cell homozygotes from heterozygotes, and overcome testing barriers …

Differentiation of sickle cell zygosity utilizing a sodium metabisulfite method

A Le, M Uppugunduri, J Korducki… - The FASEB …, 2019 - Wiley Online Library
Hemoglobinopathies are the most prevalent monogenetic disorder worldwide, and sickle
cell disease is the most prevalent and severe structural hemoglobinopathy. Globally, over …

Estimated prevalence of sickle cell in northern Haiti

TR Randolph - American Society for Clinical Laboratory Science, 2010 - clsjournal.ascls.org
OBJECTIVE: The purpose of this study is to estimate the prevalence of sickle hemoglobin in
northern Haiti. DESIGN: Sickle cell testing occurred from 2002-2009. Blood samples from …

[HTML][HTML] Comparative study of sickling test, solubility test, and hemoglobin electrophoresis in sickle cell anemia

R Nigam, B Sharda, AV Varma - MGM Journal of Medical Sciences, 2024 - journals.lww.com
Background: Madhya Pradesh, a state in India, bears the highest number of sickle cell
anemia (SCA) cases, particularly among its tribal communities. The diagnosis of suspected …

Clinical Evaluation of a Rapid Screening Test for Sickle Cell Trait (S [unknown]) and Sickle Cell Anemia (SS)

AL Louderback, Y Youhne, A Fontana… - Clinical …, 1974 - academic.oup.com
The need for a rapid screening procedure that differentiates both sickle-cell trait (S
[unknown]) and sickle-cell anemia (SS) in a single test system has led to the development of …

[PDF][PDF] Assessment of a Rapid Diagnostic Tool for Sickle Cell Hemoglobin S

O Fredrick, W Mwanda - Elixir Haematology, 2018 - researchgate.net
Sickle cell disease an inherited common blood disorder due to the presence of the abnormal
haemoglobin S. This is a prospective study done at Kenyatta National Hospital that …

Rapid screening for sickle cell disease by polymerase chain reaction-high resolution melting analysis

L Yue, M Lin, JT Chen, XF Zhan… - Molecular …, 2014 - spandidos-publications.com
Abstract Each year,~ 300,000 individuals with sickle cell disease (SCD), a
hemoglobinopathy caused by β‑globin gene mutation, are born, and> 75% of those are in …

Evaluation of paper-based point of care screening test for sickle cell disease

R Kumar, S Mishra, A Gwal, R Shanmugam - Indian Journal of Clinical …, 2021 - Springer
The aim of the study is to evaluate the stability and longevity of the paper-based screening
test for the sickle cell disease in relation to different temperatures and storage time. Blood …

Evaluation of a new screening test for sickle cell haemoglobin

J Balasubramaniam, L Phelan… - Clinical & Laboratory …, 2001 - Wiley Online Library
A new kit for screening for sickle cell haemoglobin (haemoglobin S) has been evaluated.
The kit is based on the principle that cells containing haemoglobin S, which have been …