The major driving force in the pathogenesis of pre-diabetes and Type 2 Diabetes is thought
to be chronic and low grade systemic inflammation. Immune cells are key players in the …

Introduction Cardiovascular complications are the leading cause of mortality in type 2
diabetes (T2DM), in which onset and progression of atherosclerosis is linked to chronic …

In diabetes the duration, frequency and magnitude of repeated hyperglycemia is
proportional to the incidence/severity of cardiovascular complications. While a chronic …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

An unresolved issue in autoimmunity is the lack of surrogate biomarkers of immunological
self-tolerance for disease monitoring. Here, we show that peripheral frequency of a …

Because type 1 diabetes (T1D) is a chronic, autoimmune, T cell-mediated disease,
interventions affecting T cells are expected to modulate the immune cascade and lead to …

Dendritic cells are key players in regulating immunity. These cells both activate and inhibit
the immune response depending on their cellular environment. Their response to …

Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that
leads to type 1 diabetes, yet the key features of this immune-mediated process remain …

The number of subjects with Type 2 diabetes (DM2) has risen significantly in the last ten
years. Obtaining sufficient human tissue to study this disease process as well as many other …

Immune cell function is impaired in hyperglycemic patients with diabetes but thought to
improve with normalization of blood glucose levels. In this study, we hypothesized that this …