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Research ArticleResearch and Reports

C-Reactive Protein Levels Are Elevated in Asthma and Asthma-like Conditions

Ann M. Pellizzaro and Rita M. Heuertz
American Society for Clinical Laboratory Science October 2010, 23 (4) 223-227; DOI: https://doi.org/10.29074/ascls.23.4.223
Ann M. Pellizzaro
Mayo Clinic, Jacksonville, FL 32224
MT(ASCP)
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Rita M. Heuertz
Clinical Laboratory Science Department, Doisy College of Health Sciences, Saint Louis University, St. Louis, MO 63104-1111
PhD, MT(ASCP)
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  • For correspondence: heuertzr@slu.edu
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  1. Ann M. Pellizzaro, MT(ASCP)
    1. Mayo Clinic, Jacksonville, FL 32224
  2. Rita M. Heuertz, PhD, MT(ASCP)⇑
    1. Clinical Laboratory Science Department, Doisy College of Health Sciences, Saint Louis University, St. Louis, MO 63104-1111
  1. Address for correspondence: Rita M. Heuertz, PhD, MT(ASCP), Clinical Laboratory Science Department, Doisy College of Health Sciences, Saint Louis University, 3437 Caroline Street, St. Louis, MO 63104-1111, 314-977-8610, FAX: 314-977-8503, heuertzr{at}slu.edu

Abstract

OBJECTIVE: Asthma is a chronic disease involving airway hyperresponsiveness. It was proposed that asthma/chronic shortness of breath elicit chronic systemic inflammation even in the absence of episodic events.

DESIGN: Volunteers completed questionnaires relevant to asthma and/or dyspnea and consented to C-reactive protein (CRP) quantitation. Subject groups were: control (no reported dyspnea) and asthma/shortness of breath [dyspnea] group.

SETTING: Studies were performed in the Saint Louis metropolitan area.

PARTICIPANTS: Participants consisted of volunteers aged 18-57. Inclusion criteria were good health, not pregnant, weight >110 pounds and absence of anti-inflammatory medicine use.

RESULTS: Serum CRP ranged from undetectable to 22,013 ng/mL. Mean results for asthmatic/dyspnea (n=22) and control (n=27) groups were 4,203±1,323 ng/mL and 1,741±467 ng/mL (p<0.05) respectively.

CONCLUSION: Individuals with asthma/asthma-like symptoms have chronic low levels of systemic inflammation despite the absence of episodic pulmonary events. Understanding chronic systemic inflammation relevant to asthma/asthma-like conditions may lead to design of targeted therapeutics.

ABBREVIATIONS: hsCRP = high sensitivity C-reactive protein

    INDEX TERMS
  • acute phase proteins
  • airway hyperresponsiveness
  • inflammation
  • dyspnea
  • © Copyright 2010 American Society for Clinical Laboratory Science Inc. All rights reserved.
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American Society for Clinical Laboratory Science: 23 (4)
American Society for Clinical Laboratory Science
Vol. 23, Issue 4
Fall 2010
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C-Reactive Protein Levels Are Elevated in Asthma and Asthma-like Conditions
Ann M. Pellizzaro, Rita M. Heuertz
American Society for Clinical Laboratory Science Oct 2010, 23 (4) 223-227; DOI: 10.29074/ascls.23.4.223

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C-Reactive Protein Levels Are Elevated in Asthma and Asthma-like Conditions
Ann M. Pellizzaro, Rita M. Heuertz
American Society for Clinical Laboratory Science Oct 2010, 23 (4) 223-227; DOI: 10.29074/ascls.23.4.223
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Keywords

  • acute phase proteins
  • airway hyperresponsiveness
  • inflammation
  • dyspnea

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