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- Michael McQuilkin, MT(ASCP)
- Alexander Lund, MT(ASCP)⇑
- Wyatt Palmer, MT(ASCP)
- Address for correspondence: Alex Lund MT(ASCP), 1206 22nd Street, Ogden UT 84401. (801)710-7243. AlexLund{at}mail.weber.edu
Abstract
OBJECTIVE: To evaluate antimicrobial resistance in uropathogenic bacteria in northern Utah.
DESIGN: One hundred twenty bacterial isolates from community-acquired UTI in the northern Utah area (Davis and Weber Counties) were tested. Samples were taken from otherwise healthy women, ages 18 to 50. Antimicrobial susceptibility testing for sulfamethoxazole/trimethoprim (SXT/TMP), ciprofloxacin, and nitrofurantoin comprised the process.
SETTING: The Clinical Laboratory Science Department at Weber State University, with samples coming from clinics in the northern Utah area (Davis and Weber Counties).
PARTICIPANTS: Urine samples were taken from otherwise healthy women, ages 18 to 50, who suffered from uncomplicated urinary tract infections.
MAIN OUTCOME MEASURE: Antimicrobial resistance was measured using antimicrobial susceptibility testing and shown with other national resistance rates.
RESULTS: Of bacterial isolates, 21.3% were resistant to SXT/TMP, 14.4% were resistant to ciprofloxacin, and 13.9% were resistant to nitrofurantoin. The resistance rates for ciprofloxacin and nitrofurantoin were acceptable for empirical UTI treatment (< 20% resistance), but local bacterial populations were found to demonstrate an increase in resistance to these two drugs as compared to previously observed national data. SXT/TMP resistance was above the recommended resistance threshold of 20% for effective empirical treatment, as advised by the IDSA.
CONCLUSION: Results suggest that uncomplicated community-acquired UTI be treated with nitrofurantoin. Other recommendations include continued monitoring of local uropathogenic antimicrobial resistance.
ABBREVIATIONS: ATCC = American Type Culture Collection; IDSA = Infectious Disease Society of America; NCCLS = National Committee for Clinical Laboratory Standards; SXT/TMP = sulfamethoxazole/trimethoprim; UTI = urinary tract infections.
- INDEX TERMS
- infection
- pathogen
- resistance
- urology
- Utah
- © Copyright 2007 American Society for Clinical Laboratory Science Inc. All rights reserved.