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Research ArticleResearch and Reports

Incidence, Relevance and Response for Ralstonia Respiratory Infections

Jonathan B. Waugh, Wesley M. Granger and Amit Gaggar
American Society for Clinical Laboratory Science April 2010, 23 (2) 99-106; DOI: https://doi.org/10.29074/ascls.23.2.99
Jonathan B. Waugh
Clinical and Diagnostic Sciences Department, University of Alabama at Birmingham
PhD
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  • For correspondence: waughj@uab.edu
Wesley M. Granger
Clinical and Diagnostic Sciences Department, University of Alabama at Birmingham
PhD
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Amit Gaggar
Department of Medicine, Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham
MD, PhD
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  1. Jonathan B. Waugh, PhD⇑
    1. Clinical and Diagnostic Sciences Department, University of Alabama at Birmingham
  2. Wesley M. Granger, PhD
    1. Clinical and Diagnostic Sciences Department, University of Alabama at Birmingham
  3. Amit Gaggar, MD, PhD
    1. Department of Medicine, Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham
  1. Address for Correspondence: Jonathan B. Waugh, PhD, Clinical and Diagnostic Sciences Dept., University of Alabama at Birmingham, 1705 Univ Blvd, SHPB 455, Birmingham, AL 35294-1212, 205.934.7638, waughj{at}uab.edu

Abstract

BACKGROUND: Cases of Ralstonia colonization/infection occasionally reported by hospitals has generated increased interest in an organism previously little known to most clinicians. Our goal was to determine the incidence of respiratory colonizations and infections involving Ralstonia and the association of mechanical ventilation (limited to reports on respiratory-related occurrences in the USA) and propose a decision chart to assist response.

METHODS: We performed a secondary analysis of published clinical reports of Ralstonia to determine the potential risks for respiratory colonization and infection in the USA and if being on mechanical ventilation (MV) had an influence on colonization and conversion to infection (symptomatic).

RESULTS: The odds of developing colonization with Ralstonia were eight times higher and the likelihood of developing infection with Ralstonia was twelve times higher in those mechanically ventilated compared to those not mechanically ventilated.

CONCLUSIONS: Our results suggest that individuals who are currently on mechanical ventilation and are Ralstonia culture-positive have an increased risk for colonization and may have increased propensity to the development of infection (two decision trees for approaching diagnosis and therapy included).

ABBREVIATIONS: FDA – Food and Drug Administration, sp. – Specie (spp., plural), HIV – Human Immunodeficiency Virus, MV – Mechanical Ventilation, MMWR – Morbidity and Mortality Weekly Report, PCR – Polymerase Chain Reaction, VAP – Ventilator-Associated Pneumonia

    KEY WORDS (MeSH)
  • Ralstonia
  • Gram-Negative Bacterial Infections
  • Cross Infection
  • Ventilators
  • Mechanical
  • Equipment Contamination
  • Infection
  • Equipment
  • Disposable
  • ©Copyright 2009 American Society for Clinical Laboratory Science Inc. All rights reserved.
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American Society for Clinical Laboratory Science: 23 (2)
American Society for Clinical Laboratory Science
Vol. 23, Issue 2
Spring 2010
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Incidence, Relevance and Response for Ralstonia Respiratory Infections
Jonathan B. Waugh, Wesley M. Granger, Amit Gaggar
American Society for Clinical Laboratory Science Apr 2010, 23 (2) 99-106; DOI: 10.29074/ascls.23.2.99

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Incidence, Relevance and Response for Ralstonia Respiratory Infections
Jonathan B. Waugh, Wesley M. Granger, Amit Gaggar
American Society for Clinical Laboratory Science Apr 2010, 23 (2) 99-106; DOI: 10.29074/ascls.23.2.99
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Keywords

  • Ralstonia
  • Gram-Negative Bacterial Infections
  • Cross Infection
  • Ventilators
  • Mechanical
  • Equipment Contamination
  • Infection
  • Equipment
  • Disposable

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