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Research ArticleResearch and Reports

Use of Whole-Genome Sequencing for Detection of Antimicrobial Resistance: Mycobacterium tuberculosis, a Model Organism

Vincent Escuyer
American Society for Clinical Laboratory Science April 2019, 32 (2) 85-92; DOI: https://doi.org/10.29074/ascls.2019001784
Vincent Escuyer
Wadsworth Center-New York State Department of Health
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    Figure 1.

    Principal genes involved in resistance to antituberculous drugs.

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    Figure 2.

    General workflow for TB WGS.

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American Society for Clinical Laboratory Science: 32 (2)
American Society for Clinical Laboratory Science
Vol. 32, Issue 2
1 Apr 2019
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Use of Whole-Genome Sequencing for Detection of Antimicrobial Resistance: Mycobacterium tuberculosis, a Model Organism
Vincent Escuyer
American Society for Clinical Laboratory Science Apr 2019, 32 (2) 85-92; DOI: 10.29074/ascls.2019001784

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Use of Whole-Genome Sequencing for Detection of Antimicrobial Resistance: Mycobacterium tuberculosis, a Model Organism
Vincent Escuyer
American Society for Clinical Laboratory Science Apr 2019, 32 (2) 85-92; DOI: 10.29074/ascls.2019001784
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  • Article
    • LEARNING OBJECTIVES
    • ABSTRACT
    • INTRODUCTION
    • NGS TECHNOLOGIES AND RELEVANCE TO AMR
    • DRUG RESISTANCE IN TB: CHALLENGES
    • TB: AN IDEAL CANDIDATE FOR WGS DST
    • TB WGS WORKFLOW
    • BIOINFORMATICS TOOLS
    • PERFORMANCES OF TB WGS
    • REMAINING CHALLENGES
    • CONCLUSION
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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More in this TOC Section

  • Barriers to Implementation of Quality Management Systems in Laboratories: Lessons from the Southern Africa TB Health Systems Project
  • Polyagglutination: Lectin Isolation for T-Activated Red Cells
  • Strength of Direct Antiglobulin Test as an Indicator of Disease Severity in Autoimmune Hemolytic Anemia
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Keywords

  • AMR - antimicrobial resistance
  • CDC - Centers for Disease Control and Prevention
  • DR-TB - drug resistance TB
  • DST - drug susceptibility testing
  • HCV - hepatitis C virus
  • HIV - human immunodeficiency virus
  • MDR-TB - multidrug-resistant TB
  • NGS - next-generation sequencing
  • PCR - polymerase chain reaction
  • ReSeqTB - Relational Sequencing TB Data Platform
  • TB - Mycobacterium tuberculosis
  • WGS - whole-genome sequencing
  • WHO - World Health Organization
  • XDR-TB - extensively drug-resistant TB
  • whole-genome sequencing
  • next-generation sequencing
  • antimicrobial resistance
  • Mycobacterium tuberculosis

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