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Concordance or Discordance Between ESR and hs-CRP: Are Both Tests Necessary for Patient Diagnosis?

Shannan F. McKenzie, Hind Beydoun, Rohini Ganjoo and Yuliya Dobrydneva
American Society for Clinical Laboratory Science January 2023, 36 (1) 20-26; DOI: https://doi.org/10.29074/ascls.2021003168

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Tables

  • Table 1.

    Demographic and clinical characteristics of patient population (N = 860)

    CharacteristicN (%)
    Biological sex:
     Men440 (51.16)
     Women420 (48.84)
    Age (years, mean ±SD):52.55 ± 17.36
     <50340 (39.53)
     ≥50520 (60.47)
    Health conditions:
     Malignancy24 (2.79)
     Connective tissue/musculoskeletal/autoimmune70 (8.14)
     Noninfectious organ diseases28 (3.26)
     Colitis/enteritis/other inflammatory conditions45 (5.23)
     Pericarditis/endocarditis282 (32.79)
     Diabetes35 (4.07)
     Mixed comorbidities375 (43.60)
  • Table 2.

    Cross-tabulation of hs-CRP and ESR test results

    hs-CRPESR
    Count
    Row %
    Column %    		AbnormalNormalTotal (%)
    Abnormal430222652
    (65.9%)(34.1%)(75.8%)
    (92.6%)(56.1%)
    Normal34174208
    (16.3%)(83.7%)(24.2%)
    (7.4%)(43.9%)
    Total (%)464396860
    (53.9%)(46.1%)(100%)
  • Table 3.

    Kappa statistics with 95% CIs for dichotomous ESR and hs-CRP

    Kappa (95% CI)95% CI
    Overall:0.379 (0.323, 0.436)0.3230, 0.4357
    Gender:0.368 (0.311, 0.424)0.3114, 0.4242
     Men0.377 (0.289, 0.464)0.2899, 0.4642
     Women0.361 (0.287, 0.435)0.2873, 0.4350
    Age (years):0.379 (0.322, 0.435)0.3226, 0.4353
     <500.391 (0.300, 0.482)0.3002, 0.4819
     ≥500.371 (0.299, 0.443)0.2996, 0.4433
    Malignancy:0.379 (0.323, 0.436)0.3230, 0.4357
     No0.374 (0.317, 0.431)0.3170, 0.4312
     Yes0.571 (0.225, 0.918)0.2250, 0.9178
    Connective tissue/musculoskeletal/autoimmune:0.3756 (0.319, 0.432)0.3193, 0.4323
     No0.393 (0.333, 0.452)0.3333, 0.4517
     Yes0.207 (0.019, 0.395)0.0187, 0.3952
    Noninfectious organ diseases:0.378 (0.322, 0.434)0.3218, 0.4341
     No0.391 (0.334, 0.448)0.3337, 0.4481
     Yes0.045 (-0.245, 0.336)-0.2446, 0.3355
    Colitis/enteritis/other inflammatory conditions:0.345 (0.278, 0.411)0.2783, 0.4106
     No0.385 (0.327, 0.443)0.3270, 0.4426
     Yes0.281 (0.029, 0.533)0.0297, 0.5332
    Pericarditis/endocarditis:0.346 (0.288, 0.403)0.2876, 0.4035
     No0.345 (0.278, 0.410)0.2783, 0.4106
     Yes0.349 (0.229, 0.469)0.2288, 0.4690
    Diabetes:0.378 (0.322, 0.434)0.3218, 0.4344
     No0.383 (0.325, 0.440)0.3254, 0.4404
     Yes0.267 (-0.012, 0.545)-0.0120, 0.5453
    Mixed comorbidities:0.354 (0.297, 0.412)0.2969, 0.4118
     No0.338 (0.256, 0.419)0.2564, 0.4188
     Yes0.371 (0.289, 0.452)0.2898, 0.4524
  • Table 4.

    Correlation coefficients for continuous ESR and hs-CRP

    RP value
    Overall0.426<.0001
    Gender:
     Men0.421<.0001
     Women0.444<.0001
    Age (years):
     <500.464<.0001
     ≥500.413<.0001
    Malignancy:
     No0.426<.0001
     Yes0.531.0075
    Connective tissue/musculoskeletal/autoimmune:
     No0.430<.0001
     Yes0.189.1201
    Noninfectious organ diseases:
     No0.426<.0001
     Yes0.471.0114
    Colitis/enteritis/other inflammatory conditions:
     No0.429<.0001
     Yes0.369.0126
    Pericarditis/endocarditis:
     No0.401<.0001
     Yes0.390<.0001
    Diabetes:
     No0.443<.0001
     Yes0.109.5338
    Mixed comorbidities:
     No0.390<.0001
     Yes0.471<.0001
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Concordance or Discordance Between ESR and hs-CRP: Are Both Tests Necessary for Patient Diagnosis?
Shannan F. McKenzie, Hind Beydoun, Rohini Ganjoo, Yuliya Dobrydneva
American Society for Clinical Laboratory Science Jan 2023, 36 (1) 20-26; DOI: 10.29074/ascls.2021003168
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