Article Figures & Data
Figures
- Figure 1.
MIC distributions for a single bacterium/antimicrobial pair. As shown, the wild-type population appears to be log-normally distributed at the lower MICs. COWT (ie, ECV) is the calculated wild-type cutoff value and forms the basis of the “susceptible” breakpoint. MICs greater than this are considered non–wild type.
- Figure 2.
Comparison of zone diameters with MICs of a hypothetical antimicrobial (reprinted from reference7 with permission from the publisher). For this type of study, both the MICs and zones of inhibition are determined for a series of bacterial isolates. These values are then plotted in graphical form. The numbers within the boxes refer to the number of isolates with a particular MIC (y-axis) that matches a particular zone of inhibition (x-axis). For example, there were 12 isolates with an MIC of 0.12 ug/ml that also had a 40-mm zone of inhibition. Isolates that had MICs that were in the resistant range but were susceptible by the zone of inhibition are considered to be “very major errors.” MICs that were in the susceptible range but which the zones of inhibition indicated as resistant are considered to be “major errors.” When the MICs were in the intermediate range but their zone of inhibition was either susceptible or resistant, they are considered to be “minor errors.”
Tables
- Table 1.
Various indices of several families of antimicrobial agents based on the type of antimicrobial and post-antimicrobial effect.
Antimicrobial Type PAE PK/PD Indices Antimicrobial Class Time-dependent Minimal fT > MIC Beta-lactams Minimal AUC:MIC Linezolid Extended AUC:MIC Macrolides, lincosamides, Tetracycline family Concentration-dependent Extended fCmax:MIC Glycopeptides Minimal AUC:MIC Polymyxins Extended AUC:MIC and/or fCmax:MIC Aminoglycosides, quinolones, streptogramins, ketolides, Daptomycin Adapted from Turnridge and Patterson.8
Jump to section
Related Articles
Cited By...
- No citing articles found.
More in this TOC Section
Similar Articles
Keywords
- AST - antimicrobial susceptibility testing
- AUC - area under the curve
- BMD - broth microdilution
- CFU - colony-forming unit
- CLSI - Clinical and Laboratory Standards Institute
- CSF - cerebral spinal fluid
- ECV - epidemiologic cut-off value
- EMA - European Medicines Agency
- EUCAST - European Committee on Antimicrobial Susceptibility Testing
- fCmax - peak free drug concentration
- FDA - Food and Drug Administration
- fT - free drug concentration
- I - intermediate
- MIC - minimum inhibitory concentration
- NS - nonsusceptible
- NWT - non–wild type
- PAE - post-antimicrobial effect
- PCR - polymerase chain reaction
- PD - pharmacodynamics
- PK - pharmacokinetics
- R - resistant
- S - susceptible
- SDD - susceptible dose-dependent
- USCAST - National Antimicrobial Susceptibility Testing Committee for the United States
- UTI - urinary tract infection
- WT - wild type
- antimicrobial susceptibility testing
- antimicrobial resistance