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Research ArticleResearch and Reports

Molecular Action of ADAMTS-13 and Transfusion Therapies of Thrombotic Thrombocytopenic Purpura

Billie Ketelsen
American Society for Clinical Laboratory Science July 2020, 33 (3) 32-36; DOI: https://doi.org/10.29074/ascls.2020002287
Billie Ketelsen
Oakland University
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Article Information

vol. 33 no. 3 32-36
DOI 
https://doi.org/10.29074/ascls.2020002287

Published By 
American Society for Clinical Laboratory Science
Print ISSN 
0894-959X
Online ISSN 
1945-3574
History 
  • Received February 12, 2020
  • Revision received May 8, 2020
  • Accepted June 4, 2020
  • Published online December 21, 2023.

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  • Latest version (April 27, 2023 - 08:19).
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© 2020 © 2020 The American Society for Clinical Laboratory Science American Society for Clinical Laboratory Science

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American Society for Clinical Laboratory Science: 33 (3)
American Society for Clinical Laboratory Science
Vol. 33, Issue 3
1 Jul 2020
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Molecular Action of ADAMTS-13 and Transfusion Therapies of Thrombotic Thrombocytopenic Purpura
Billie Ketelsen
American Society for Clinical Laboratory Science Jul 2020, 33 (3) 32-36; DOI: 10.29074/ascls.2020002287

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Molecular Action of ADAMTS-13 and Transfusion Therapies of Thrombotic Thrombocytopenic Purpura
Billie Ketelsen
American Society for Clinical Laboratory Science Jul 2020, 33 (3) 32-36; DOI: 10.29074/ascls.2020002287
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  • Article
    • LEARNING OBJECTIVES
    • ABSTRACT
    • INTRODUCTION
    • GENETIC MUTATIONS AND CONGENITAL TTP
    • INHIBITORS AND ACQUIRED TTP
    • TRANSFUSION THERAPY FOR ACQUIRED TTP
    • CONCLUSION
    • References
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Keywords

  • ADAMTS-13 - a disintegrin and metalloproteinase with a thrombospondin type 1 motif - member 13
  • CPP - cryoprecipitate-poor plasma
  • CUB - complement C1r/C1s, Uegf, Bmp1
  • FFP - fresh frozen plasma
  • FP24 - plasma frozen within 24 hours after phlebotomy
  • IgG - immunoglobulin G
  • IgM - immunoglobulin M
  • LDH - lactate dehydrogenase
  • TP - thawed plasma
  • TPE - therapeutic plasma exchange
  • TSP - thrombospondin
  • TTP - thrombotic thrombocytopenic purpura
  • ULVWF - ultra-large von Willebrand factor
  • VWF - von Willebrand factor
  • ADAMTS-13
  • autoantibodies
  • IgG
  • thrombotic thrombocytopenic purpura
  • therapeutic plasma exchange

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