Article Figures & Data
Figures
- Figure 1.
Domain structure of ADAMTS-13. ADAMTS-13 is composed of a metalloproteinase (proteolytic domain), TSP-1–like domains for a total of 8 domains, a cysteine-rich/spacer motif, and 2 CUB structures (peptide-containing domains). The N-terminal domain of ADAMTS-13 is composed of the metalloproteinase, disintegrin, TSP-1, and the cysteine-rich/spacer domains. The C-terminal domains include TSP-2–TSP-8 and the 2 CUB structures.
- Figure 2.
Cryptic epitopes in the spacer domain that are targeted by autoantibodies to ADAMTS-13.
Tables
Reference Range Original Laboratory Results (Day 1) Day 2 Day 3 Hematology Platelet bil/L 150–400 32 22 37 Chemistry LDH U/L 100–240 362 240 190 Blood bank Plasma volume exchange 0 mL 3000 mL 3000 mL Day 4 Day 5 Day 6 Day 7 (After TPE) Hematology Platelet bil/L 91 112 175 195 Chemistry LDH U/L 176 159 147 152 Blood bank Plasma volume exchange 3000 mL 3500 mL 3500 mL 3500 mL Treatment was a 6-day course of plasma exchange at 10–15 mL/kg body weight. During treatment, platelet values and LDH values were closely monitored. Platelet values steadily increased throughout treatment, whereas LDH values decreased to within normal range.
Jump to section
Related Articles
Cited By...
- No citing articles found.
More in this TOC Section
Similar Articles
Keywords
- ADAMTS-13 - a disintegrin and metalloproteinase with a thrombospondin type 1 motif - member 13
- CPP - cryoprecipitate-poor plasma
- CUB - complement C1r/C1s, Uegf, Bmp1
- FFP - fresh frozen plasma
- FP24 - plasma frozen within 24 hours after phlebotomy
- IgG - immunoglobulin G
- IgM - immunoglobulin M
- LDH - lactate dehydrogenase
- TP - thawed plasma
- TPE - therapeutic plasma exchange
- TSP - thrombospondin
- TTP - thrombotic thrombocytopenic purpura
- ULVWF - ultra-large von Willebrand factor
- VWF - von Willebrand factor
- ADAMTS-13
- autoantibodies
- IgG
- thrombotic thrombocytopenic purpura
- therapeutic plasma exchange