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Research ArticleFocus: Interpreting the Complete Blood Count

A Methodical Approach to Interpreting the Platelet Parameters of the Complete Blood Count

Kathy Doig and Michelle Butina
American Society for Clinical Laboratory Science July 2017, 30 (3) 194-201; DOI: https://doi.org/10.29074/ascls.30.3.194
Kathy Doig
Professor Emeritus, Biomedical Laboratory Diagnostics Program, Michigan State University, E. Lansing, MI
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  • For correspondence: doig@msu.edu
Michelle Butina
Associate Professor, Medical Laboratory Science Program, University of Kentucky College of Health Sciences, Lexington, KY
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    Figure 1.

    The equation for estimating a platelet count is shown.

  • Figure 2.
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    Figure 2.

    Platelet histogram for case study 1. The dotted line represents a normal histogram. The solid line represents the patient histogram.

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    Figure 3.

    Platelet histogram for case study 2. The dotted line represents a normal histogram. The solid line represents the patient histogram.

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    Figure 4.

    Platelet histogram for case study 3. The dotted line represents a normal histogram. The solid line represents the patient histogram.

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    Figure 5.

    Representative microscopic field for Case 3. (Magnification × 1000)

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    Table 1.

    The steps for interpreting the platelet portion of a complete blood count.

    1. Interpret the total platelet count relative to the reference interval.
    2. Examine the MPV and compare to the reference interval.
    3. Examine the PDW and compare to the reference interval.
    4. Examine the platelet distribution histogram for evidence of interferences. Take steps to correct these and reassess Steps 1-3 based on the revised results.
    5. Examine the IPF and compare to the reference interval.
    6. Correlate the numerical parameters with platelet morphology.
    7. Correlate platelet results with rbc and wbc parameters and conduct clinical assessment of the patient's values.
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    Table 2.

    Platelet Parameter Results for Case 1.

    AssayPatientReference Interval
    Platelet count ( × 103/μL)713150-450
    MPV (fL)108-12
    PDW (fL)139-15
    HistogramRefer to Figure 2.Refer to Figure 2.
    IPF (%)50.5-7
    Platelet MorphologyNo abnormalities noted.Normal
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    Table 3.

    Platelet Parameter Results for Case 2

    AssayPatientReference Interval
    Platelet count ( × 103/μL)19150-450
    MPV (fL)148-12
    PDW (fL)169-15
    HistogramRefer to Figure 3.Refer to Figure 3.
    IPF (%)120.5-7%
    Platelet MorphologyFew giant platelets noted.Normal
    • View popup
    Table 4.

    Platelet Parameter Results for Case 3

    AssayPatientReference Interval
    Platelet count ( × 103/μL)116150-450
    MPV (fL)98-12
    PDW (fL)119-15
    HistogramRefer to Figure 4.Refer to Figure 4.
    IPF (%)30.5-7%
    Platelet MorphologyRefer to Figure 5.Normal
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American Society for Clinical Laboratory Science: 30 (3)
American Society for Clinical Laboratory Science
Vol. 30, Issue 3
Summer 2017
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A Methodical Approach to Interpreting the Platelet Parameters of the Complete Blood Count
Kathy Doig, Michelle Butina
American Society for Clinical Laboratory Science Jul 2017, 30 (3) 194-201; DOI: 10.29074/ascls.30.3.194

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A Methodical Approach to Interpreting the Platelet Parameters of the Complete Blood Count
Kathy Doig, Michelle Butina
American Society for Clinical Laboratory Science Jul 2017, 30 (3) 194-201; DOI: 10.29074/ascls.30.3.194
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  • A Methodical Approach to Interpreting the White Blood Cell Parameters of the Complete Blood Count
  • The Rationale for a Methodical Approach to Interpreting the Complete Blood Count and Its Development
  • A Methodical Approach to Interpreting the Red Blood Cell Parameters of the Complete Blood Count
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Keywords

  • Platelet counts
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