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Research ArticleResearch and Reports

Past, Present, and Future Options in the Treatment of Hemophilia A

Donna D. Castellone
American Society for Clinical Laboratory Science January 2019, 32 (1) 36-42; DOI: https://doi.org/10.29074/ascls.2018001032
Donna D. Castellone
NewYork Presbyterian Hospital, Columbia Medical Center
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Article Information

vol. 32 no. 1 36-42
DOI 
https://doi.org/10.29074/ascls.2018001032

Published By 
American Society for Clinical Laboratory Science
Print ISSN 
0894-959X
Online ISSN 
1945-3574
History 
  • Received August 6, 2019
  • Accepted August 7, 2019
  • Published online February 7, 2023.

Copyright & Usage 
© 2019 © 2019 The American Society for Clinical Laboratory Science American Society for Clinical Laboratory Science

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American Society for Clinical Laboratory Science: 32 (1)
American Society for Clinical Laboratory Science
Vol. 32, Issue 1
1 Jan 2019
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Past, Present, and Future Options in the Treatment of Hemophilia A
Donna D. Castellone
American Society for Clinical Laboratory Science Jan 2019, 32 (1) 36-42; DOI: 10.29074/ascls.2018001032

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Past, Present, and Future Options in the Treatment of Hemophilia A
Donna D. Castellone
American Society for Clinical Laboratory Science Jan 2019, 32 (1) 36-42; DOI: 10.29074/ascls.2018001032
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  • Article
    • LEARNING OBJECTIVES
    • ABSTRACT
    • INTRODUCTION
    • HISTORY OF TREATMENT
    • PRESENT-DAY TREATMENT OPTIONS
    • MANAGEMENT OF HEMOPHILIA
    • TREATMENT IN THE PRESENCE OF INHIBITORS
    • IMMUNE TOLERANCE INDUCTION
    • GENE THERAPY
    • NONFACTOR THERAPY
    • CONCLUSION
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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  • Strength of Direct Antiglobulin Test as an Indicator of Disease Severity in Autoimmune Hemolytic Anemia
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Keywords

  • AA - aminocaproic acid
  • AAV - adeno-associated virus
  • AAV5 - adeno-associated virus serotype 5
  • AT - antithrombin
  • BHK - baby hamster kidney
  • BU - Bethesda units
  • CHO - Chinese hamster ovary
  • DDAVP - desmopressin
  • EHL - extended half-life
  • FIX - factor IX
  • FIXa - activated factor IX
  • VII - factor VII
  • FVIII - factor VIII
  • FX - factor X
  • ITI - immune tolerance induction
  • ITRs - inverted terminal repeats
  • IU - international units
  • PEG - polyethylene glycol
  • PUPs - previously untreated patients
  • rFVIIa - recombinant activated factor VII
  • rFvIII - recombinant factor VIII
  • TA - tranexamic acid
  • TFPI - tissue factor pathway inhibitor
  • VWF - von Willebrand factor
  • hemophilia A
  • factor VIII
  • recombinant
  • prophylaxis
  • half-life

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