Past, Present, and Future Options in the Treatment of Hemophilia A

Donna D. Castellone

doi:10.29074/ascls.2018001032

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Table 1.

Factor levels to manage bleeds

Severity of Bleed	Type of Bleed	Desired FVIII Level	*Dosage
Mild hemorrhages	Early hemarthrosis, epistaxis, gingival bleeding	30 IU	1–3 doses FVIII
Major hemorrhages	Late hemarthrosis, muscle bleeds	50 IU	Many doses, with continuous monitoring of FVIII levels
Life-threatening bleed	Major trauma or operation, advanced or recurrent hemarthrosis, major gastrointestinal bleeding, head trauma, compromise of limb or compartment syndrome	80–100 IU	Continuous infusions

*The formula for patient dosage to determine the number of units of FVIII to correct the activity level is as follows: Dose in FVIII IU = (wt in kg) × (desired FVIII increase (IU)) × (0.5 IU/kg per IU/dL).